| Date | Competition | Opponents | Venue | Score | Goalscorers | Att | Rep | Vid |
|---|---|---|---|---|---|---|---|---|
| 12/08/2000 | Div 1 | STOCKPORT COUNTY | H | 1-3 | Butters | 9429 |  | |
| 09/09/2000 | Div 1 | Grimsby Town | A | 0-1 | 4512 | | ||
| 13/09/2000 | Div 1 | Queens Park Rangers | A | 2-2 | Asaba,Hessenthaler | 10655 | | |
| 16/09/2000 | Div 1 | HUDDERSFIELD TOWN | H | 2-1 | Butters,Smith | 8503 | | |
| 20/09/2000 | FLC2 | Manchester City | A | 1-1 | Smith | 17408 | | |
| 23/09/2000 | Div 1 | Fulham | A | 0-3 | 13032 | | ||
| 26/09/2000 | FLC2 | MANCHESTER CITY | H | 2-4 (aet) | Thomson(2) | 6520 | | |
| 30/09/2000 | Div 1 | SHEFFIELD WEDNESDAY | H | 2-0 | Butters,Thomson | 9099 | | |
| 06/10/2000 | Div 1 | BOLTON WANDERERS | H | 2-2 | Smith,Onuora | 9311 | | |
| 14/10/2000 | Div 1 | Wimbledon | A | 4-4 | Thomson(2),Saunders,Asaba | 9030 | | |
| 17/10/2000 | Div 1 | Watford | A | 0-0 | 12356 | | ||
| 21/10/2000 | Div 1 | BARNSLEY | H | 0-0 | 9030 | | ||
| 25/10/2000 | Div 1 | Birmingham City | A | 0-1 | 26044 | | ||
| 28/10/2000 | Div 1 | CREWE ALEXANDRA | H | 0-1 | 8347 | | ||
| 04/11/2000 | Div 1 | Sheffield Utd | A | 2-1 | Smith,Thomson | 14028 | | |
| 12/11/2000 | Div 1 | NOTTINGHAM FOREST | H | 1-3 | Onuora | 9884 | | |
| 18/11/2000 | Div 1 | West Bromwich Albion | A | 1-3 | King | 16410 | | |
| 25/11/2000 | Div 1 | Blackburn Rovers | A | 2-1 | Hessenthaler,OG | 18061 | | |
| 02/12/2000 | Div 1 | BIRMINGHAM CITY | H | 1-2 | King | 9247 | | |
| 09/12/2000 | Div 1 | Norwich City | A | 0-1 | 16725 | | ||
| 16/12/2000 | Div 1 | PRESTON NORTH END | H | 4-0 | Asaba(2),Ashby,King | 8198 | | |
| 22/12/2000 | Div 1 | Stockport County | A | 2-2 | Lewis,King | 6095 | | |
| 26/12/2000 | Div 1 | CRYSTAL PALACE | H | 4-1 | Asaba(3),Onuora | 10518 | | |
| 01/01/2001 | Div 1 | Portsmouth | A | 0-0 | 14526 | | ||
| 06/01/2001 | FAC3 | Bournemouth | A | 3-2 | Hope,Hessenthaler,Shaw | 7403 | | |
| 13/01/2001 | Div 1 | BURNLEY | H | 0-0 | 9331 | | ||
| 20/01/2001 | Div 1 | Crystal Palace | A | 2-2 | Saunders(2) | 18823 | | |
| 28/01/2001 | FAC4 | CHELSEA | H | 2-4 | Shaw,Onuora | 10419 | | |
| 03/02/2001 | Div 1 | Wolverhampton Wanderers | A | 1-1 | King | 26627 | | |
| 10/02/2001 | Div 1 | GRIMSBY TOWN | H | 1-0 | King | 8633 | | |
| 17/02/2001 | Div 1 | Huddersfield Town | A | 3-2 | Saunders(2),King | 10576 | | |
| 20/02/2001 | Div 1 | QUEENS PARK RANGERS | H | 0-1 | 10432 | | ||
| 24/02/2001 | Div 1 | FULHAM | H | 0-2 | 9931 | | ||
| 03/03/2001 | Div 1 | Sheffield Wednesday | A | 1-2 | Asaba | 18702 | | |
| 06/03/2001 | Div 1 | WIMBLEDON | H | 0-0 | 8841 | | ||
| 10/03/2001 | Div 1 | Bolton Wanderers | A | 3-3 | King(2),Southall | 13161 | | |
| 20/03/2001 | Div 1 | TRANMERE ROVERS | H | 2-1 | King(p),Onuora | 7810 | | |
| 25/03/2001 | Div 1 | Barnsley | A | 1-3 | King | 13609 | | |
| 31/03/2001 | Div 1 | Preston North End | A | 0-0 | 13550 | | ||
| 07/04/2001 | Div 1 | NORWICH CITY | H | 4-3 | Hope,Onuora(3) | 9608 | | |
| 14/04/2001 | Div 1 | SHEFFIELD UTD | H | 4-1 | Onuora,King(2),Shaw | 9502 | | |
| 16/04/2001 | Div 1 | Crewe Alexandra | A | 1-2 | Hope | 7051 | | |
| 21/04/2001 | Div 1 | WEST BROMWICH ALBION | H | 1-2 | Onuora | 9920 | | |
| 28/04/2001 | Div 1 | Nottingham Forest | A | 1-0 | King | 20670 | | |
| 01/05/2001 | Div 1 | WATFORD | H | 0-3 | 9098 | | ||
| 06/05/2001 | Div 1 | BLACKBURN ROVERS | H | 1-1 | King(p) | 10319 | |